Glossary / Data and Analysis Description

Glossary

  • Age: in years, between 16 and 55 years
  • APACHE II Score: Acute Physiology And Chronic Health Evaluation II is one of many disease severity scoring systems. An integer score from 0-71 is assigned during the first 24 hours of admission to an ICU and is based on clinical parameters such as blood pressure, temperature, and heart rate. The higher the score the more severe the physiological abnormalities.
  • Complicated recovery: was defined as maximum MOF > 6 and >=14 days to MOF recovery.
  • Cluster
    • Cluster is a set of Affymetrix probe sets with expression values that behave similarly over the time points
    • for normal response: FDR<0.001 & FC>2
    • for complications: FDR<0.001 & FC>2
    • Assigned Cluster      The cluster which a probe-set is associated.
    • Closest Cluster:   when there is no value for an Assigned Cluster column, this is the closest matching cluster for the time course expression data. When there is a Cluster entry, this entry is the same as the Cluster entry.
  • Days Since Injury: The time since the injury event, in days. "0.5" represents the first collection sample occurring within the first 12 hours of the injury event.
  • Emergency Department Base deficit: The patient's worst base deficit recorded during the first 6 hours of resuscitation. Base deficit represents the accumulation of blood products (organic acids) indicative of inadequate resuscitation, perfusion and hypoxia. A measure of the severity of the injury.
  • Emergency Department lowest systolic blood pressure: The patient¼s lowest systolic blood pressure recorded in the ER during resuscitation in mmHg.
  • False discovery rate (FDR): The probability of finding a difference in gene expression between study groups when no change or difference exists. This probability is the basis for the q value and is similar to Type 1 or alpha error. 
  • Fold Change (FC): Ratio of change in genetic expression based on either uncomplicated recovery or control subject gene expression profiles.   
  • Gene Name: The gene name(s) chosen by the query.
  • Gene Symbol: The gene symbol(s) chosen by the query
  • Heat map:  a graphical representation of DNA/RNA microarray data to illustrate changes in genetic expression. For the heat map figures represented in the manuscript, red represents increased expression whereas blue represents decreased expression.  
  • Hospital length of stay: The total hospital length of stay in days.
  • ICU total length of stay: The total intensive care unit length of st*ay in days.
  • Injury Severity Score (ISS): is an anatomic based injury severity scoring system that is based on the AIS score (see above). The 3 highest body region scores of the AIS are squared and then added together to produce a value from 0-75. If there is any injury in the AIS that is a 6 indicative of an unsurvivable injury, the ISS score is automatically designated to be 75.
  • Intermediate Recovery: A categorical variable representing those injured subjects whose recovery could not be classified into either uncomplicated or complicated. Represented a maximum MOF score >6, but recovery (TOR) occurred within 5 - 14 days.
  • Marshall score:  a disease severity scoring systems that includes 6 organ components: respiratory, renal, hepatic, cardiovascular, hematologic, and neurologic evaluation. For the present study, the neurologic component was excluded.  The values represent the sum of 5 organ components with higher numbers representing increased illness severity. For the study, patients with Marshall scores greater than 6 were classified as having multisystem organ failure. Click here for exact parameters used to calculate Marshall score.
  • Max AIS score not including head injury: Abbreviated Injury Scale (AIS) is an anatomic based injury severity scoring system. A number, 1-6, is assigned per anatomic region with larger numbers indicating increased injury. Anatomic regions include head and neck, face, chest, abdomen, extremity, and spine.
  • Maximum MOF (Marshall score): The classic Marshall score is one of many disease severity scoring systems that includes 6 organ components: respiratory, renal, hepatic, cardiovascular, hematologic, and neurologic evaluation. For the present study, the neurologic component was excluded. The values represent the sum of 5 organ components with higher numbers representing increased organ dysfunction.
  • Measured daily: maximum recorded daily value
  • Multiorgan failure: organ dysfunction in more than one organ system. In the current study, this was defined as a Marshall score greater than 6.
  • Nosocomial Infection (Y/N): Nosocomial infections that occurred during the hospital admission after injury such as urinary tract infections, ventilator associated pneumonia, and surgical site infections.
  • Probe set:  a collection of probes designed to detect a given gene’s expression.
  • q-Value: an “adjusted” p value to determine the significance of changes in gene expression between study groups in relation to the FDR. This value is similar to p value.
  • RespType : Patient recovery classified as either uncomplicated or complicated.
  • Sex: gender, as in male or female
  • Surgical site infections (Y/N): Surgical site infections during the hospital admission after injury.
  • Survival (Y/N): 28 day patient survival after severe blunt trauma.
  • Synonym Names: synonym gene names per the AffymetrixTM annotation.
  • Synonym Symbols: synonym gene symbols per the AffymetrixTM annotation.
  • Time to Recovery (ToR): These values represent the length of time in days for a given patient to return to an absence of organ failure, defined as recovery of ALL organ systems to the following parameters:
    • Respiratory:   Cessation of mechanical ventilation or a PaO2/FiO2 >300 and PEEP <8, whichever comes first
    • Cardiovascular:  Cessation of inotropic or vasopressor support and MAP (mean arterial pressure) over 60 and cardiac index over 3 (if available)
    • Hematologic:  Platelet count > 120
    • Renal:   Serum creatinine <3 mg/dl without renal replacement therapy
    • Hepatic: Total bilirubin <3 mg/dl
  • Transfused blood 0-12 hours since injury: The total volume of blood products that the patient received in milliliters during the first 12 hours post injury.
  • Uncomplicated Recovery (Yes/No/Other): A categorical variable defining whether the patient¼s recovery could be classified as being uncomplicated or not. An uncomplicated recovery was defined as maximum MOF < 6 and <= 5 days to MOF recovery.

Data and Analysis Methods






Data and Analysis Description

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